• Imaris offers a great set of tools for the visualization of time-resolved 3D microscopy data.

Dr. Gaudenz Danuser and colleagues from the Laboratory for Computational Cell Biology (LCCB) work on computational methods for quantitative, high-resolution microscopy and multi-scale models to study the action of complex, multifunctional molecular machinery and signaling networks in the context of live cells. They develop quantitative light microscopy and numerical models of cytoskeleton mechanics to study the molecular regulation of cell migration and chromosome segregation in normal physiology and disease.

Gaudenz Danuser received his diploma in Geodetic Engineering in 1993 and graduated in 1997 with a Ph.D. in Computer Vision from ETH Zurich, Switzerland. In 2001 he got promoted to the rank of an Assistant Professor for Cell Biomechanics in the Department of Mechanical and Process Engineering at the ETH Zürich. In August 2003 Gaudenz Danuser moved back to the U.S. to set up the LCCB in the new Center of Integrated Molecular Biosciences (CIMBio) at the Scripps Research Institute, La Jolla.

The image on theright shows an Imaris view of a low-pass filtered 3D image data stack displaying two GFP-tags, which indicate the position of the spindle pole body (green) and the centromere of chromosome IV (red) in interphase (G1). Trajectory was measured using LCCB's own ChromDyn software package and ImarisXT.

Dr. Gaudenz says: “We use Imaris because it offers a great set of tools for the visualization of time-resolved 3D microscopy data. Graphical perfection is Imaris' signature, distinguishing an Imaris figure immediately from any other data representation published in the scientific literature.”

“Because of ImarisXT my lab can exploit this graphical power in combination with the analytical software we develop to address questions about specific cellular and molecular mechanisms.”